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Medications that trigger hair shedding
Every medication on the Shed Clock, with what its label or the literature actually reports. We never advise starting, stopping or changing a medicine.
| Trigger | Sourced onset | Sourced duration / settling | On calculator |
|---|---|---|---|
| GLP-1 medications | weeks 8–16 | weeks 26–39 | Yes |
| Mounjaro & Zepbound (tirzepatide) | weeks 8–16 | weeks 26–39 | Yes |
| Lamotrigine (Lamictal) | varies | varies | No |
| Valproate (Depakote) | varies | varies | No |
| Isotretinoin (Accutane) | varies | varies | No |
| Sertraline & SSRIs | varies | varies | No |
| Anticoagulants (Eliquis, Xarelto, warfarin) | varies | varies | No |
| Levothyroxine changes | varies | varies | No |
GLP-1 medications
Hair loss is listed in the Wegovy (semaglutide 2.4 mg) prescribing information in about 3% of adults versus 1% on placebo…
MedicationsMounjaro & Zepbound (tirzepatide)
The Zepbound label lists hair loss in 4–5% of patients versus 1% on placebo…
MedicationsLamotrigine (Lamictal)
In a review of pharmacovigilance reports of lamotrigine-associated alopecia…
MedicationsValproate (Depakote)
DermNet lists valproic acid as causing hair loss in 12–28% of users…
MedicationsIsotretinoin (Accutane)
A systematic review of 22 studies found hair loss in 3.2% of acne patients on isotretinoin below 0.5 mg/kg/day versus 5.7% on 0.5 mg/kg/day or more…
MedicationsSertraline & SSRIs
Hair loss is a rare reported side effect of sertraline…
MedicationsAnticoagulants (Eliquis, Xarelto, warfarin)
DermNet lists heparin and warfarin among drugs that cause telogen effluvium and says newer anticoagulants such as rivaroxaban…
MedicationsLevothyroxine changes
Levothyroxine labelling says partial hair loss may occur rarely during the first few months of therapy and is usually temporary.…